Optimal - The Blog
April 26, 2025
Moderate coffee consumption—around three to four cups per day—has been linked to a significantly lower risk of chronic liver diseases, including non-alcoholic steatohepatitis (NASH), cirrhosis, and liver cancer.
The key protective compounds in coffee, caffeine and chlorogenic acids, appear to reduce inflammation, slow the development of liver fibrosis, and support anti-cancer activity in liver cells.
These compounds work by suppressing fibrotic proteins and promoting healthy cell turnover, providing both antioxidant and antifibrotic benefits.
Importantly, studies show that all types of coffee—whether caffeinated, decaffeinated, instant, or ground—offer protective effects, with a UK study reporting nearly a 50% reduction in liver disease mortality among coffee drinkers.
Regular coffee intake is also linked to a reduced risk of non-alcoholic fatty liver disease (NAFLD) and progression to fibrosis. Additionally, drinking two more cups of coffee daily is associated with a 35% lower risk of hepatocellular carcinoma (HCC), regardless of whether the coffee contains caffeine.
While these findings are promising, more rigorous research is needed to confirm coffee’s full preventive and therapeutic potential for liver health.
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