The most common age-related brain disorders worldwide are stroke, dementia, and late-life depression, which is associated with cognitive decline. These conditions share risk factors that can be controlled, including physical activity, nutrition, and tobacco smoking.
Based on these modifiable factors, a Brain Care Score (BCS) can help you gauge your brain health and risk of common brain disorders (Singh 2024).
The BCS results range from 0-21 and are based on:
4 physical components
- Blood pressure
- Hemoglobin A1c
- Cholesterol
- Body Mass Index (BMI)
5 lifestyle elements
- Nutrition
- Alcohol intake
- Smoking
- Aerobic activities
- Sleep
3 social-emotional factors
- Stress
- Relationships
- Purpose in life
Data gathered from over 400,000 participants in the UK biobank study found that each 5-point increase in baseline BCS score was associated with a 33% reduced risk of late-life depression and a 27% reduced risk of combined outcomes, including dementia, late-life depression, and stroke. Optimal results based on BCS criteria include (Singh 2024):
- Blood pressure below 120/80 mmHg
- Hemoglobin A1C below 5.7%
- Total cholesterol below 190 mg/dL (4.92 mmol/L)
- BMI between 18.5 and 25 kg/m2
- 3 or more of the following:
- 5 servings of fruit and vegetables per day
- 2 servings of lean protein per day
- 3 or more servings of whole grains per day
- Less than 1,500 mg of sodium per day
- Less than 36 ounces of sugar-sweetened beverages (soda, juice, etc.) per week
- Alcohol intake: 0-1 drinks per week
- Tobacco smoking: Never smoked or quit more than a year ago
- Aerobic activity: At least 150 minutes of moderate physical activity (ex. walking) or 75 minutes of high-intensity physical activity per week
- Sleep: 7-8 hours per night
- Stress: Manageable levels of stress that rarely make it difficult to function
- Social relationships: At least 2 people besides a spouse or children, that you feel close to and could discuss private matters with or call upon to help
- Meaning in life: You generally feel that your life has meaning and/or purpose
Brain Care Score Questionnaire
Optimal Takeaways and key actions to improve your BCS (Mass General)
- Control your blood pressure
- Only ~25% of adults with high blood pressure have it under control
- Controlling blood pressure can dramatically reduce your risk of dementia and stroke
- Maintain a healthy weight, minimize sodium from processed foods, be active, e.g., walk, dance, or bike regularly, use weight lifting to build muscle, limit alcohol intake to 0-1 drink per day, and address stress with deep breathing or meditation to control stress hormones that can increase blood pressure.
- Avoid overeating and other unhealthy habits
- Adopt a Mediterranean-style diet and include:
- More leafy greens, at least 1 cup raw or a half cup cooked daily
- Colorful fruits & veggies, e.g., avocadoes, berries, blueberries, broccoli, eggplant, and red peppers
- Extra virgin olive oil
- Seafood high in omega-3 EPA and DHA e.g., wild salmon, sardines, cod, mussels, and oysters
- Nuts, seeds, and beans/legumes, aim for a total of one half to one whole cup daily, e.g., almonds, cashews, walnuts, pumpkin seeds, black beans, and lentils
- Spices and herbs, e.g., cinnamon, cloves, nutmeg, turmeric, ginger, and saffron
- Fermented foods, e.g., buttermilk, yogurt, curd, kefir, kombucha, and kimchi
- Dark chocolate
- Avoid alcohol and smoking
- Exercise
- At least 150 minutes per week but set reasonable goals for where you are at the moment
- Get quality sleep
- Prioritize sleep, using a sleep diary to evaluate your sleep schedule and how it may affect your daytime alertness
- Maintain a comfortable sleep environment and be consistent with bedtime and number of hours set aside for sleep
- Avoid reading, working, and screen time in bed if sleep is suboptimal
- Avoid alcohol, caffeine, and other stimulants within six hours of bedtime
- Try something relaxing before bed, such as a hot bath or mindfulness practice
- Reduce stress
- Meditation or relaxation techniques can help control your response to stress and minimize its negative effects
- Self-reflection and evaluating your thoughts, feelings, and behaviors can help manage stress and improve brain health
- Build healthy relationships
- Learn new things
- Strive for meaning and purpose in life
The Sustainable Mediterranean Diet
Source: Serra-Majem, Lluís et al. “Updating the Mediterranean Diet Pyramid towards Sustainability: Focus on Environmental Concerns.” International journal of environmental research and public health vol. 17,23 8758. 25 Nov. 2020, doi:10.3390/ijerph17238758 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license
References
Singh, Sanjula D et al. “The predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank cohort.” Frontiers in psychiatry vol. 15 1373797. 23 Jul. 2024, doi:10.3389/fpsyt.2024.1373797 This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Massachusetts General Hospital. Interested in improving your McCance Brain Care Score? https://www.massgeneral.org/neurology/mccance-center/research/brain-care-now
McCance Brain Care Score. https://www.massgeneral.org/assets/mgh/pdf/neurology/mccance-center/brain-care-score.pdf
NPR. You can reduce your risk of dementia. Here's how to get started. Nov25 2024. https://www.npr.org/sections/shots-health-news/2024/11/22/nx-s1-5050956/health-brain-dementia-sleep-diet-alzheimers