Evaluating the ratio between triglycerides and HDL-C (TG:HDL) helps assess cardiometabolic risk and provides clues about lipid metabolism.
An increase in triglycerides and a decrease in HDL suggest dysfunction as an increased ratio is associated with cardiovascular disease, glucose intolerance, metabolic syndrome, diabetes, high blood pressure, non-alcoholic fatty liver disease, and abdominal obesity.
An elevated ratio in adolescents should be investigated further as it is strongly associated with metabolic syndrome in this population, a condition that can be addressed early with healthy diet and lifestyle changes.
Research suggests that an increased TG:HDL is also associated with small dense low-density lipoproteins, the type that are considered highly atherogenic.
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