Pregnenolone Comes From Cholesterol

Pregnenolone is a crucial molecule produced from cholesterol. It is a precursor to several hormones, including cortisol, DHEA, estrogen, progesterone, and testosterone. Pregnenolone has anti-inflammatory, immune regulatory, and neuroprotective properties, supports cognition, and potentially protects against Alzheimer's, multiple sclerosis, autism, and schizophrenia.

Low pregnenolone levels can be seen in conditions such as schizophrenia, chronic alcohol intake, type 2 diabetes, and adrenal dysfunction, while high levels may occur with pregnenolone supplementation or enzyme deficiencies. Studies have found that pregnenolone supplementation may improve functional capacity in schizophrenic patients and reduce chronic back pain in military veterans.

The balance of sulfated pregnenolone in the brain may play a role in mood disorders like anxiety and depression, while impaired production of pregnenolone in the hypothalamus may contribute to cognitive dysfunction in obesity-related metabolic disorders.

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