Optimal DX FYI: 5-deiodinase Disruption Disrupts Your Thyroid

Thyroid hormones regulate several metabolic functions, including heart rate, temperature regulation, calcium balance, and fat and carbohydrate metabolism.

The 5-deiodinase enzyme is responsible for converting inactive T4 thyroid hormone into active T3. Disruption of this conversion can lead to hypothyroidism, even if tyrosine and iodine intake are adequate.

Symptoms of Hypothyroidism 

• Cholesterol elevations
• Cognitive deficits
• Cold hands and feet
• Constipation
• Depression, mood swings
• Fatigue
• Forgetfulness
• Hair that is dry and coarse
• Heavy menstruation
• Low energy
• Muscle pain
• Weight gain

Be sure to address these factors when evaluating thyroid sufficiency:

Factors that disrupt 5-deiodinase 

• • Free radicals and oxidative stress
  • Illness
  • Liver disease, leading to increased reverse T3
  • Medications
  • Protein insufficiency
  • Selenium insufficiency
  • Stress, cortisol
  • Suboptimal nutrition
  • Toxic metals, including mercury, cadmium, and lead

Reference

Raymond, Janice L., et al. Krause and Mahan's Food & the Nutrition Care Process. Elsevier, 2021.

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