Medium LDLs are Not So Great Either

Research suggests that small LDL particles are more closely linked to an increased risk of cardiovascular disease (CVD). However, medium-sized LDL particles may also contribute to this risk.

Medium LDLs are associated with an atherogenic pattern called phenotype B, which in turn is associated with smaller LDLs, larger HDLs, increased triglycerides, and a higher risk of CVD, metabolic syndrome, insulin resistance, and type 2 diabetes. Genetic factors can influence LDL and HDL size, and medium LDLs have been linked to increased coronary artery calcium and cardiac risk in high-risk individuals.

Low levels of medium LDLs suggest a lower risk of cardiovascular disease. In contrast, high levels may be associated with genetic factors, increased triglycerides, decreased HDL-C, and an increased risk of CVD, metabolic syndrome, and diabetes.

Medium LDL levels can be measured using ion mobility technology.

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