GlycA is a significant marker of systemic inflammation and has become an important biomarker for evaluating cardiovascular, metabolic, and autoimmune disorders. High levels are linked to various inflammatory conditions, including obesity, insulin resistance, metabolic syndrome, type 2 diabetes, cardiovascular disease, hypertension, lupus, psoriasis, arthritis, infection, and immune activation.
As GlycA levels increase, disease severity also rises, prompting further investigation into the underlying causes of inflammation. Adopting a healthy lifestyle, including a nutrient-rich diet and regular exercise, can help lower elevated GlycA levels. Combining exercise with weight loss and dietary improvements can significantly reduce GlycA.
Low GlycA levels generally indicate low inflammation, but this is not true for sickle cell anemia due to hemolytic destruction of red blood cells.
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