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September 28, 2021

Magnesium Deficiency Can Break Your Heart

There are so many reasons to pay close attention to magnesium, the fourth most abundant mineral in the human body. One of the most important ones is the vital role that it plays in cardiovascular health, from maintaining the integrity of blood vessels to keeping your heart beating.

If you want to reduce your risk of cardiovascular disease, and keep your heart, mind, and body healthy, keep magnesium in mind.

Main Functions of Magnesium

  • A crucial component of more than 325 metabolic enzymes
  • Maintains elasticity of blood vessels
  • Helps maintain healthy blood pressure and blood glucose
  • Regulates collagen, elastin turnover
  • Maintains healthy bone
  • Helps process omega-3 and omega-6 fatty acids
  • Supports antioxidant activity
  • Improves tolerance to stress

Cardiovascular-Related Conditions Associated with Magnesium Deficiency

  • Atherosclerosis
  • Cardiac arrhythmia
  • Decreased antioxidant activity
  • Depression
  • High blood pressure
  • Hyperglycemia
  • Increased hs-CRP, IL-6, fibrinogen
  • Inflammation, including vascular inflammation
  • Insulin resistance
  • Lipid disorders
  • Metabolic syndrome
  • Stroke
  • Type 2 diabetes

Source: Kostov, Krasimir, and Lyudmila Halacheva. “Role of Magnesium Deficiency in Promoting Atherosclerosis, Endothelial Dysfunction, and Arterial Stiffening as Risk Factors for Hypertension.” International journal of molecular sciences vol. 19,6 1724. 11 Jun. 2018, doi:10.3390/ijms19061724 [R] This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.

Consequences of Magnesium Deficiency

General

Anxiety, agitation, irritability, headache, loss of appetite, nausea

Musculature

muscle spasm and tetany

Central Nervous System, nerves

Nervousness, migraine, depression, poor memory, low-stress tolerance, paraesthesia, tremor, seizures, neuropsychiatric disorders

Cardiovascular system

High blood pressure

Risk of arrhythmias, coronary spasm, atherosclerosis, endothelial dysfunction, vascular inflammation, arterial stiffness, vascular ECM remodeling, arterial calcification, vascular aging,

increased platelet aggregation, potentiates vasoconstriction

Electrolytes

Sodium retention, hypokalemia, and hypocalcemia

Metabolism

Dyslipoproteinemia, insulin resistance, pancreatic beta-cell dysfunction, decreased glucose tolerance,

increased risk of metabolic syndrome and type 2 diabetes, disorders of vitamin D metabolism, resistance to PTH, osteoporosis

Pregnancy

Pregnancy complications (e.g., eclampsia)

Gastrointestinal tract

Constipation

Fortunately, there is an easy, convenient way to avoid magnesium deficiency… consume, absorb, and retain enough magnesium to meet your needs. Adults need to consume approximately 6 mg per kg of body weight. So, for someone that weighs 150 pounds or 68 kg, they would need at least 408 mg of magnesium per day. Any losses from sweat or from the GI system must be replaced.

Unfortunately, up to 82% of adults don’t consume enough magnesium, especially as we get older. Much of this deficit comes from excess intake of highly processed foods and a Western-style diet. Processing and boiling alone can remove up to 85% of magnesium from food.

The best sources of magnesium include dark leafy green vegetables, whole grains, nuts, and legumes. Fruits, chocolate, meats. and fish are good sources as well, while dairy products are poor sources. Drinking water may or may not be a source of magnesium, depending on its processing. Researchers suggest that consumption of 10-100 mg/L of magnesium in drinking water may help improve the magnesium status of communities, especially those with low intake.

Magnesium supplements are best absorbed when bound to compounds such as aspartate, gluconate, and citrate for the highest bioavailability.

Blood levels of magnesium shouldn’t drop below 2 mg/dL (0.85 mmol/L). Too much isn’t good either. Blood levels greater than 19.5 mg/dL (8 mmol/L) can be toxic and cause hypotension, vasodilation, drowsiness, and cardiac complications.

Magnesium is one of those things that you just can’t live without… so don’t!

References

Kostov, Krasimir, and Lyudmila Halacheva. “Role of Magnesium Deficiency in Promoting Atherosclerosis, Endothelial Dysfunction, and Arterial Stiffening as Risk Factors for Hypertension.” International journal of molecular sciences vol. 19,6 1724. 11 Jun. 2018, doi:10.3390/ijms19061724
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.

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