The ratio between Apo B (associated with LDL and atherogenic) and Apo A-1 (associated with HDL and protective) is a key indicator for assessing the risk of cardiovascular diseases (CVD), including advanced atherosclerosis, myocardial infarction (MI), stroke, metabolic syndrome, and diabetic complications.
A low Apo B to Apo A-1 ratio signifies decreased CVD risk due to reduced atherogenic Apo B and increased protective Apo A-1.
Conversely, a high ratio increases the risk of various cardiometabolic disorders.
Studies have found that this ratio is a better tool for evaluating coronary artery disease than traditional biomarkers like total cholesterol or lipid ratios.
A ratio of 0.865 or above is considered a significant independent risk factor, tripling the risk of major cardiovascular events. This ratio is also significantly correlated with the severity of atherosclerosis and has been associated with metabolic syndrome risk.
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