Folate, a B vitamin, is essential for various metabolic processes, including the production of blood cells and DNA synthesis. Its deficiency, often linked to a lack of dietary intake or vitamin B12 insufficiency, can lead to severe health conditions such as neural tube defects and megaloblastic anemia.
Measuring red blood cell (RBC) folate is the best method to evaluate long-term folate levels, reflecting both recent intake and liver storage. High RBC folate levels can indicate recent transfusion or prolonged supplementation.
While fortification with synthetic folic acid has decreased the occurrence of folate-related health issues, overuse can disrupt folate, B12, and homocysteine metabolism, making 5-MTHF the preferred form of supplemental folate.
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