IgE: Allergies and Beyond

Immunoglobulin E (IgE) plays a key role in diagnosing allergies and is associated with immune reactions that can be severe and even fatal. It triggers symptoms such as swelling, itching, rhinitis, asthma, and difficulty breathing. High IgE levels are observed in cases of allergies, asthma, eczema, and infections.

IgE facilitates an allergic response by binding to mast cell and basophil receptors, leading to degranulation and the production of cytokines and eicosanoids. While it can effectively defend against parasitic infections, IgE can also mount an allergic response to less harmful environmental antigens, causing type 1 hypersensitivity reactions and potentially fatal systemic anaphylaxis.

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