Ceruloplasmin is an Unsung Hero

Ceruloplasmin is an important protein that binds copper and assists in its deliver to cells as well as its excretion from the body. Ceruloplasmin also oxidizes iron and assists in its safe transport through the blood. Without ceruloplasmin, iron would accumulate in the liver. Ceruloplasmin also helps keep iron away from pathogenic microbes that could otherwise use it for their growth.

Ceruloplasmin levels will decrease with copper deficiency, malnutrition, and low protein intake, and low levels are associated with Wilson's disease and Menke's disease. 

Elevated ceruloplasmin may be associated with copper toxicity, zinc deficiency, Alzheimer's, cancer, rheumatoid arthritis, atrial fibrillation, cardiac dysfunction, and neurodegenerative disease. It is also an acute-phase reactant and can increase temporarily with inflammation, infection, arthritis, and trauma.

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