Myeloperoxidase (MPO) is a fascinating enzyme that serves as both defender and potential troublemaker in our bodies. Primarily found in white blood cells called neutrophils, MPO plays a crucial role in our immune system's first line of defense against pathogens.This powerful enzyme produces hypochlorous acid - essentially the same active ingredient found in household bleach - to destroy invading microorganisms. However, like many powerful tools in biology, MPO's activity is a double-edged sword. While it helps protect us from infection, elevated levels of MPO in the bloodstream can signal underlying inflammation and oxidative stress, making it an increasingly important biomarker in modern medicine.
Given MPO's role in inflammation and oxidative stress, elevated levels of this enzyme can signal active disease processes across several acute conditions:
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