LDH is lactate dehydrogenase, a type of metabolic enzyme that assists in the generation of energy, especially when oxygen availability is low. It facilitates the conversion of pyruvate to lactate and vice versa, creating an energy substrate with flexible use.
LDH is found in many tissues in the body including the liver, kidney, heart, lung, and muscle. When any of these tissues are damaged, a form of LDH can be released and measured in the blood.
Increased levels can be seen with metabolic syndrome, poorly controlled diabetes, myocardial infarction, lung disease, kidney disease, muscle injury, infections, inflammation, alcohol, certain medications, and pesticide exposure.
Low levels are not as common but may be seen with genetic disorders and excess vitamin C intake.
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