Elevated uric acid is traditionally a red flag and a potential indicator of gout. However, mounting research indicates that rising uric acid may also be associated with cardiometabolic and cognitive risk.
Higher uric acid is associated with specific cardiovascular risk factors, including diabetes, metabolic syndrome, and hypertension. It is also associated with an increased risk of stroke and insulin resistance.
The doubling of uric acid levels in the United States is suspected of being associated with high-purine foods, alcohol, and high-fructose soft drinks.
In view of the close association between increased uric acid and disease, the ODX upper ranges for uric acid have been updated from:
Male: 3.50 - 5.90 mg/dL (208.18 – 350.96 umol/L)
Female: 3.00 – 5.5 mg/dL (178.44 - 327.17 umol/L)
To
Male: 3.50 - 5.40 mg/dL (208.18 – 321.19 umol/L)
Female: 3.00 – 4.70 mg/dL (178.44 - 279.57 umol/L)
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